منابع مشابه
actin: to polymerize or not to polymerize
© The Rockefeller University Press $8.00 The Journal of Cell Biology, Vol. 172, No. 4, February 13, 2006 495–496 http://www.jcb.org/cgi/doi/10.1083/jcb.200601095 JCB 495 The form and function of actin in the nucleus have been enigmatic for over 30 years. Recently actin has been assigned numerous functional roles in the nucleus, but its form remains a mystery. The intricate relationship between ...
متن کاملNuclear actin: to polymerize or not to polymerize
The form and function of actin in the nucleus have been enigmatic for over 30 years. Recently actin has been assigned numerous functional roles in the nucleus, but its form remains a mystery. The intricate relationship between actin form and function in the cytoplasm implies that understanding the structural properties of nuclear actin is elementary to fully understanding its function. In this ...
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Introduction Polymerases are fascinating and ubiquitous enzymes that catalyse the synthesis of nucleic acids with impressive rates and fidelity. Indeed, polymerases are capable of distinguishing minute differences in nucleoside triphosphates (e.g. the 2'OH residue that is absent in dNTPs but present in rNTPs) and process with very low error rates (~106 for Pfu DNA polymerase, e.g.). However, th...
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Thinking of a computer as an educational tool emphasizes a solitary interaction between the learner and the computer. A tool is something that is applied to an object in order to change it, and this usually implies a single user working on a single object or project. While tools are an important aspect of an educational experience, the tool metaphor can isolate individual learners from each oth...
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Abst rac t : This paper discusses the kind of in fo rmat ion that must be present in a computer program that models the l i n g u i s t i c development of a c h i l d . A three stage model is presented that character izes the development of a na tu ra l l a n guage parser in a c h i l d of ages one, one and a h a l f , and two. Some data from ch i ld ren of these ages is presented. General prob...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2010
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn2823